IL-34 Proteins, cDNA Clones Research Reagents

IL34 (Interleukin 34, also known as IL-34; C16orf77), located on 16q22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog. The gene produces a 27482 Da protein composed of 242 amino acids. Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R). Diseases such as Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 and Tenosynovial Giant Cell Tumor are associated with IL34. The related pathways of IL34 include PEDF Induced Signaling and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions.

IL-34 Protein (2)

    IL-34 cDNA Clone (39)

    NM_152456.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001135100.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_848059.2

    克隆载体 cDNA 产品

    In lentiviral vector

    IL-34 Lysate (2)

      IL-34 分子背景

      IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R). IL-34 protein is expressed in various tissues, including heart, brain, lung, liver, kidney, spleen, thymus, testes, ovary, small intestine, prostate, and colon, and most abundant in the spleen. The colony-stimulating factor 1 receptor (CSF-1R) is identified as the receptor for IL-34. IL-34 increases the growth or survival of immune cells known as monocytes. Besides, IL-34 promoted the formation of the colony-forming unit-macrophage (CFU-M), a macrophage progenitor, in human bone marrow cultures.

      IL-34 参考文献

      • Lin H, et al. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science. 320(5877): 807-11.

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