IL-4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL4 (Interleukin 4, also known as BSF1; IL-4; BCGF1; BSF-1; BCGF-1), located on 5q31.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 17492 Da protein composed of 153 amino acids. The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. Diseases such as Schistosomiasis and Vernal Conjunctivitis are associated with IL4. The related pathways of IL4 include the Immune response Fc epsilon RI pathway and PEDF Induced Signaling.

IL-4 Protein (6)

    IL-4 Antibody (15)

      IL-4 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      IL-4 cDNA Clone (60)

      BC067514

      In lentiviral vector

      NM_021283.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_201270.1

      克隆载体 cDNA 产品

      In lentiviral vector

      P79339-1

      In expression vector

      NM_001032904.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001003159.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL-4 Lysate (1)

        IL-4 分子背景

        Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibits in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.

        IL-4 参考文献

        • Grunewald SM. et al., 1998, J Immunol. 160 (8): 4004-9.
        • Susanne M. et al, 1997, THE JOURNAL OF BIOLOGICAL CHEMISTRY. 272 (3): 1480-3.
        • Nishikubo K. et al., 2003, Gene Ther. 10 (26): 2119-25.

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