IL-6 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL6 (Interleukin 6, also known as CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2), located on 7p15.3, is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, and chicken. The gene produces a 23718 Da protein composed of 212 amino acids. IL6 is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL6 has been defined as an essential role in directing the transition from innate to acquired immunity.

IL-6 Protein (6)

IL-6 Antibody (26)

    IL-6 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

    IL-6 cDNA Clone (66)

    NM_000600.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_031168.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_012589.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001042733.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001003301.1

    克隆载体 cDNA 产品

    In lentiviral vector

    IL-6 分子背景

    Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.

    IL-6 参考文献

    • Heinrich PC. et al. (2003). Principles of interleukin-6-type cytokine signalling and its regulation. Biochem J. 374: 1-20.
    • Rose-John S, et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets. 11(5): 613-24.
    • Dinh W, et al. (2009) Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders. Cardiovasc Diabetol. 8:58.

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