IL11 Proteins, Antibodies, cDNA Clones Research Reagents

IL11 (Interleukin 11, also known as AGIF; IL-11), located on 19q13.42, is a Protein Coding gene. The gene produces a 21429 Da protein composed of 199 amino acids. IL11 is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha. Diseases such as Hemorrhagic Cystitis and Plasmacytoma are associated with IL11. The related pathways of IL11 include Interleukin-11 Signaling Pathway and PEDF Induced Signaling.

IL11 Protein (3)

    IL11 Antibody (2)

      IL11 cDNA Clone (40)

      BC012506

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008350.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_133519.3

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_005595782.2

      In expression vector

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      IL11 分子背景

      IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 is also known under the names adipogenesis inhibitory factor (AGIF) and oprelvekin. IL11 can improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis. IL11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. As a signaling molecule, IL11 has a variety of functions associated with its receptor interleukin 11 receptor alpha; such functions include placentation and to some extent of decidualization.

      IL11 参考文献

      • McKinley D. et al., 1992, Genomics. 13 (3): 814-9.
      • Paul SR. et al., 1990, Proc Natl Acad Sci. 87 (19): 7512-6.
      • Kawashima I. et al., 1991, FEBS Lett. 283 (2): 199-202.

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