IL12B Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL12B (Interleukin 12B, also known as CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B), located on 5q33.3, is a Protein Coding gene. The gene produces a 37169 Da protein composed of 328 amino acids. IL12B is a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The IL12 p40 subunit, or IL12B, heterodimerizes with the IL12 p35 subunit (IL12A) to form IL12 and with the IL23 p19 subunit (IL23A) to form IL23. Diseases such as Immunodeficiency 29 and Takayasu Arteritis are associated with IL12B.

IL12B Protein (9)

    IL12B Antibody (15)

      IL12B ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL12B cDNA Clone (91)

      NM_002187.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008352.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_022611.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_002744108.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_002710347.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001044725.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001003292.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL12B Lysate (9)

        IL12B 分子背景

        Subunit beta of interleukin 12 (also known as natural killer cell stimulatory factor 2, or cytotoxic lymphocyte maturation factor 2, p40) (IL12B) is a subunit of human interleukin 12. IL12B/IL-12B is a cytokine that acts on T and natural killer cells and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor-like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. IL12B/IL-12B is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine is important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. IL12B/IL-12B associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine that functions in innate and adaptive immunity.

        IL12B 参考文献

        • Taoufik Y, et al. (1997) Human immunodeficiency virus gp120 inhibits interleukin-12 secretion by human monocytes: an indirect interleukin-10-mediated effect. Blood. 89 (8): 2842-8.
        • Fantuzzi L, et al. (1996) Induction of interleukin-12 (IL-12) by recombinant glycoprotein gp120 of human immunodeficiency virus type 1 in human monocytes/macrophages: requirement of gamma interferon for IL-12 secretion. J Virol. 70 (6): 4121-4.
        • Aragane Y, et al. (1995) IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J Immunol. 153 (12): 5366-72.

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