IL17RA Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL17RA (Interleukin 17 Receptor A, also known as CD217; IL17R; IMD51; CANDF5; CDw217; IL-17RA; hIL-17R), located on 22q11.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish. The gene produces a 96122 Da protein composed of 866 amino acids. Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. Diseases such as Immunodeficiency 51 and Chronic Mucocutaneous Candidiasis are associated with IL17RA. The related pathways of IL17RA include IL-17 Family Signaling Pathways and Akt Signaling.

IL17RA Protein (11)

    IL17RA Antibody (15)

      IL17RA ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL17RA cDNA Clone (39)

      NM_014339.4

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008359.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001107883.2

      克隆载体 cDNA 产品

      In lentiviral vector

      IL17RA Lysate (9)

        IL17RA 分子背景

        Interleukin-17 receptor (IL-17R), also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217), is a cytokine receptor that binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails, and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans.

        IL17RA 参考文献

        • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9 (8): 556-67.
        • Johansen C, et al.. (2009) Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160 (2): 319-24.
        • Yao Z, et al.. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800.

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