IL17RB Proteins, Antibodies, cDNA Clones Research Reagents

IL17RB (Interleukin 17 Receptor B, also known as CRL4; EVI27; IL17BR; IL17RH1), located on 3p21.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 55885 Da protein composed of 502 amino acids. The protein encoded by this gene is a cytokine receptor. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. Diseases such as Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis are associated with IL17RB. The related pathways of IL17RB include IL-17 Family Signaling Pathways and PEDF Induced Signaling.

IL17RB Protein (6)

    IL17RB Antibody (5)

      IL17RB cDNA Clone (52)

      NM_018725.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_019583.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001107290.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001082504.2

      克隆载体 cDNA 产品

      In lentiviral vector

      IL17RB Lysate (6)

        IL17RB 分子背景

        IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGFbeta. Overexpression of IL17RB is associated with poor prognosis and the short survival of breast cancer patients.IL17RB/IL17B signaling triggers a substantial increase in cell growth, proliferation, and migration through the activation of NF-kappaB as well as the up-regulation of the Bcl-2. IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics. Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.

        IL17RB 参考文献

        • Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
        • Stock P, et al.. (2009) Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB. J Immunol. 182(8): 5116-22.
        • Wang H, et al.. (2010) Allergen challenge of peripheral blood mononuclear cells from patients with seasonal allergic rhinitis increases IL-17RB, which regulates basophil apoptosis and degranulation. Clin Exp Allergy. 40(8): 1194-202.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.