IL17RD Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL17RD (Interleukin 17 Receptor D, also known as SEF; HH18; IL-17RD; IL17RLM), located on 3p14.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces an 82411 Da protein composed of 739 amino acids. This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. Diseases such as Hypogonadotropic Hypogonadism 18 With Or Without Anosmia and Kallmann Syndrome are associated with IL17RD. The related pathways of IL17RD include RET signaling and Signaling by GPCR.

IL17RD Protein (3)

    IL17RD Antibody (5)

      IL17RD ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL17RD cDNA Clone (13)

      NM_017563.3

      克隆载体 cDNA 产品

      In lentiviral vector

      IL17RD qPCR Primer (1)

      IL17RD Lysate (3)

        IL17RD 分子背景

        Interleukin-17 receptor D (IL-17D) also known as Interleukin-17 receptor-like protein, is a member of the interleukine-17 receptor family. IL-17RD functions as a feedback inhibitor of fibroblast growth factor-mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation and may be involved in apoptosis. IL-17RD is found expressed in the neopallial cortex, rhombic lip, and dorsal regions of the myelencephalon and the frontal nasal process. IL-17RD is also expressed in the commissural plate and septal area of the forebrain and the hippocampus, lens, and optic cup. In the oral region, IL-17RD is expressed in the tongue and the mesenchyme of the first branchial arch. It is also expressed in the developing inner ear. IL-17RD interacts with both IL-17R-Myc and IL-17RB-Myc. Both the intracellular and extracellular domains of IL-17RD interact with IL-17R. IL-17R forms a heteromeric complex with IL-17RD. Experiment results indicate that IL-17RD can affect IL-17R localization, suggesting that these two molecules are colocalized and associate with each other within cells. The fact that IL-17RD Delta ICD is unable to mediate IL-17 signaling but functions as a dominant-negative form indicates that the intracellular domain of IL-17RD is pivotal. Also, IL-17RD interacts with the IL-17R downstream molecule TRAF6. It has been proposed that the IL-17RD intracellular domain interacts with IL-17R and TRAF6 to deliver the downstream signal.

        IL17RD 参考文献

        • Weaver CT, et al.. (2007) IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol. 25: 821-52.
        • Rong Z, et al.. (2009) IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Cell Res. 19(2): 208-15.
        • Gaffen SL. (2009) Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9(8): 556-67.

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