IL18BP Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All IL18BP reagents are produced in house and quality controlled, including 7 IL18BP Antibody, 1 IL18BP ELISA, 26 IL18BP Gene, 4 IL18BP Lysate, 4 IL18BP Protein, 2 IL18BP qPCR. All IL18BP reagents are ready to use.

IL18BP Protein (4)

    IL18BP Antibody (7)

      IL18BP ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL18BP cDNA Clone (26)

      NM_001039659.1

      In expression vector

      NM_010531.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_053374.2

      IL18BP Lysate (4)

        IL18BP 分子背景

        Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated, resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation, which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.

        IL18BP 参考文献

        • Novick D, et al.. (2001) A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine. 14(6): 334-42.
        • Mazodier K, et al.. (2005) Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome. Blood. 106(10): 3483-9.
        • Akira S. (2000) The role of IL-18 in innate immunity. Curr Opin Immunol. 12(1): 59-63.

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