IL-18Rα Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL18R1 (Interleukin 18 Receptor 1, also known as CD218a; IL18RA; IL1RRP; CDw218a; IL-1Rrp; IL-18Ralpha; IL18Ralpha2; IL-18R-alpha), located on 2q12.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 62304 Da protein composed of 541 amino acids. The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. Diseases such as Laron Syndrome and Smallpox are associated with IL18R1. The related pathways of IL18R1 include the Immune response IL-23 signaling pathway and Akt Signaling.

IL-18Rα Protein (12)

IL-18Rα Antibody (18)

    IL-18Rα ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(4)

    IL-18Rα cDNA Clone (49)

    NM_003855.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_008365.1

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001106905.2

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_005625993.1

    In lentiviral vector

    IL-18Rα Lysate (11)

      IL-18Rα 分子背景

      Interleukin-18 receptor 1 (IL18R1) also known as CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, and CD218a, is an interleukin receptor of the immunoglobulin superfamily. IL18R1 is found expressed in the lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from the brain, skeletal muscle, pancreas, and kidney. A high level of expression is found in Hodgkin disease cell lines. This receptor is specifically bound to interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target. The absence of a genetic association in the IL18R1 gene itself suggests regulation from other parts of the genome, or as part of the inflammatory cascade in multiple sclerosis without a prime genetic cause.

      IL-18Rα 参考文献

      • Nadif R, et al.. (2006) IL18 and IL18R1 polymorphisms, lung CT and fibrosis: A longitudinal study in coal miners. Eur Respir J. 28(6): 1100-5.
      • Haralambieva IH, et al.. (2011) Common SNPs/haplotypes in IL18R1 and IL18 genes are associated with variations in hum oral immunity to smallpox vaccination in Caucasians and African Americans. J Infect Dis. 204(3): 433-41.
      • Hulin-Curtis SL, et al.. (2012) Evaluation of IL18 and IL18R1 polymorphisms: genetic susceptibility to knee osteoarthritis. Int J Immunogenet. 39(2): 106-9.

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