IL2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL2 (Interleukin 2, also known as IL-2; TCGF; lymphokine), located on 4q27, is conserved in chimpanzee, Rhesus monkey, dog, mouse, and rat. The gene produces a 17628 Da protein composed of 153 amino acids. IL2 is a powerfully immunoregulatory lymphokine that is produced by lectin- or antigen-activated T cells. IL2 is useful in the study of the molecular nature of T-cell differentiation and, like interferons, augments natural killer cell activity. Diseases such as Capillary Leak Syndrome and Tropical Spastic Paraparesis are associated with IL2.

IL2 Protein (8)

    IL2 Antibody (22)

      IL2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      IL2 cDNA Clone (78)

      BC066257

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008366.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_053836.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001003305.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001163180.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001047130.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL2 Lysate (1)

        IL2 分子背景

        Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleukin-2 / IL-2 molecule was first purified to homogeneity by immunoaffinity chromatography by Kendall Smith and his team at Dartmouth Medical School. Interleukin-2 / IL-2 was also the first cytokine shown to mediate its effects via a specific IL-2 receptor, and it was also the first interleukin to be cloned and expressed from a complementary DNA (cDNA) library. Interleukin-2 / IL-2 was designated number 2 because Smith's data at the time indicated that IL-1, produced by macrophages, facilitates IL-2 production by T lymphocytes (T cells).
        Interleukin-2 / IL-2 is produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Interleukin-2 / IL-2 is normally produced by the body during an immune response. When environmental substances (molecules or microbes) gain access to the body, these substances (termed antigens) are recognized as foreign by antigen receptors that are expressed on the surface of lymphocytes. Antigen binding to the T cell receptor (TCR) stimulates the secretion of Interleukin-2 / IL-2 and the expression of IL-2 receptors IL-2R. The IL-2 / IL-2R interaction then stimulates the growth, differentiation, and survival of antigen-selected cytotoxic T cells via the activation of the expression of specific genes. Interleukin-2 / IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. The World Reference Standard for Interleukin-2 / IL-2 is produced by the National Institute of Biological Standards and Control in the UK. A recombinant form of Interleukin-2 / IL-2 for clinical use is manufactured by Chiron Corporation with the brand name Proleukin. It has been approved by the Food and Drug Administration (FDA) for the treatment of cancers (malignant melanoma, renal cell cancer), and is in clinical trials for the treatment of chronic viral infections, and as a booster (adjuvant) for vaccines. The use of Interleukin-2 / IL-2 in HIV therapy is ineffective.

        IL2 参考文献

        • Smith KA, et al.,1980,  J. Exp. Med.151 (6): 1551-6. 
        • Smith KA, et al.,1980, Nature. 287 (5785): 853-5.
        • Taniguchi T, et al.,1983, Nature. 302 (5906): 305.
        • Cantrell DA, et al.,1984, Science. 224 (4655): 1312-6. 
        • Smith KA, et al.,1988, Science. 240 (4856): 1169-76.
        • Wang X. et al., 2005, Science 310:1159-63.
        • Stauber D.J. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 2788-93.

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