IL22RA1 Proteins, cDNA Clones Research Reagents

IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1, also known as IL22R; CRF2-9; IL22R1), located on 1p36.11, is conserved in chimpanzee, dog, cow, mouse, rat, and chicken. The gene produces a 63077 Da protein composed of 574 amino acids. The protein encoded by this gene belongs to the class II cytokine receptor family and is a receptor for interleukin 22 (IL22). Diseases such as Spondyloarthropathy and Intestinal Tuberculosis are associated with IL22RA1. The related pathways of IL22RA1 include Th17 cell differentiation and Akt Signaling.

IL22RA1 Protein (4)

    IL22RA1 cDNA Clone (39)

    NM_021258.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001191869.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_850020.2

    克隆载体 cDNA 产品

    In lentiviral vector

    IL22RA1 Lysate (4)

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      IL22RA1 分子背景

      IL-22R belongs to the type II cytokine receptor family. It contains 2 fibronectin type-III domains and is expressed in the colon, liver, lung, pancreas, and kidney. IL-22R also can be expressed in keratinocytes of normal skin as well as in psoriatic skin lesions. Overexpression of IL-22R can be detected in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients. IL-22R is a component of the receptor for IL20, IL22, and IL24. The component of IL-22R formed by IL22RA1 and IL10RB enables IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptors for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. IL-22R mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

      IL22RA1 参考文献

      • Xie MH, et al. (2000) Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem. 275(40):31335-9.
      • Xu W, et al. (2001) A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci. 98(17):9511-6.
      • Wu PW, et al. (2008) IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22. J Mol Biol. 382(5):1168-83.

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