IL25 Proteins, Antibodies, cDNA Clones Research Reagents

IL25 (Interleukin 25, also known as IL17E), located on 14q11.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 20330 Da protein composed of 177 amino acids. The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. The IL17E protein shares 16 to 20% identity with IL17 (IL17), IL17B, and IL17C. Diseases such as Nail Disease and Chronic Mucocutaneous Candidiasis are associated with IL25. The related pathways of IL25 include IL-17 Family Signaling Pathways and PEDF Induced Signaling.

IL25 Protein (4)

    IL25 Antibody (4)

      IL25 cDNA Clone (40)

      NP_073626.1

      In expression vector

      NM_080729.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001192007.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_005623236.1

      克隆载体 cDNA 产品

      In lentiviral vector

      IL25 qPCR Primer (2)

      IL25 Lysate (4)

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        IL25 分子背景

        Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity. IL-25 promotes cell expansion and Th2 cytokine production when Th2 central memory cells are stimulated with thymic stromal lymphopoietin (TSLP)–activated dendritic cells (DCs), homeostatic cytokines, or T cell receptor for antigen triggering. Elevated expression of IL-25 and IL-25R transcripts was observed in asthmatic lung tissues and atopic dermatitis skin lesions, linking their possible roles with exacerbated allergic disorders. A plausible explanation that IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of adaptive Th2 memory cells had been provided.

        IL25 参考文献

        • Rickel EA, et al.. (2008) Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J Immunol. 181(6): 4299-310.
        • Tamachi T, et al.. (2006) IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol. 118(3): 606-14.
        • Kleinschek MA, et al.. (2007) IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med. 204(1): 161-70.

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