IL3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

IL3 (Interleukin 3, also known as IL-3; MCGF; MULTI-CSF), located on 5q31.1, is a Protein Coding gene. The gene produces a 17233 Da protein composed of 152 amino acids. The protein encoded by this gene is a potent growth-promoting cytokine. IL3 is involved in a variety of cell activities such as cell growth, differentiation, and apoptosis. Diseases such as Mastocytosis, Cutaneous and Megakaryocytic Leukemia are associated with IL3. The related pathways of IL3 include Transcriptional misregulation in cancer and RET signaling.

IL3 Protein (5)

    IL3 Antibody (16)

      IL3 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      IL3 cDNA Clone (9)

      BC069472

      In lentiviral vector

      IL3 qPCR Primer (1)

      IL3 Lysate (4)

        IL3 分子背景

        IL3 (interleukin 3), also known as IL-3, is a potent growth-promoting cytokine that belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation, and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.

        IL3 参考文献

        • Meyer CG, et al.. (2011) IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. Hum Mol Genet. 20(6):1173-81.
        • Zambrano A, et al. (2010) IL-3 controls tau modifications and protects cortical neurons from neurodegeneration. Curr Alzheimer Res. 7(7):615-24.
        • Dentelli P, et al.. (2011) IL-3 is a novel target to interfere with tumor vasculature. Oncogene. 30(50):4930-40.

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