Inhibin beta B Proteins, Antibodies, cDNA Clones Research Reagents

INHBB (Inhibin Subunit Beta B), located on 2q14.2, is conserved in Rhesus monkey, cow, mouse, rat, chicken, and zebrafish. The gene produces a 45122 Da protein composed of 407 amino acids. The activins, dimers of beta-A or beta-B subunits encoded by the genes Inhba and Inhbb, respectively, are TGF-beta (transforming growth factor-beta) superfamily members that have roles in reproduction and development. Diseases such as Eclampsia and Pre-Eclampsia are associated with INHBB. The related pathways of INHBB include Signaling by GPCR and PEDF Induced Signaling.

Inhibin beta B Protein (1)

    Inhibin beta B Antibody (1)

      Inhibin beta B cDNA Clone (13)

      NM_002193.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Inhibin beta B qPCR Primer (1)

      Inhibin beta B Lysate (1)

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        Inhibin beta B 分子背景

        Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two ß subunits, ßA ßA (activin A), ßB ßB (activin B), or ßA ßB (activin AB). Inhibin is composed of an alpha and one of two ß subunits, ßA (inhibin A) or ßB (inhibin B). Activins are produced in many cell types and organs, such as gonads, pituitary gland, and placenta. In the ovarian follicle, activin increases FSH binding and FSH-induced aromatization. It participates in androgen synthesis enhancing LH action in the ovary and testis. In the male, activin enhances spermatogenesis. Also, Activin plays a role in wound repair and skin morphogenesis. Activin is strongly expressed in wounded skin, and overexpression of activin in the epidermis of transgenic mice improves wound healing and enhances scar formation. Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and kidney. There is also evidence showed that lack of activin during development results in neural developmental defects.

        Inhibin beta B 参考文献

        • Feng ZM, et al. (1989) Characterization and regulation of testicular inhibin beta-subunit mRNA. Mol Endocrinol. 3 (6): 939-48.
        • Bernard DJ, et al. (2002) Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor. Mol Endocrinol. 16 (2): 207-12.
        • Lejeune H, et al. (1997) Stimulating effect of both human recombinant inhibin A and activin A on immature porcine Leydig cell functions in vitro. Endocrinology. 138 (11): 4783-91.

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