Insulin Receptor Proteins, Antibodies, cDNA Clones Research Reagents

All Insulin Receptor reagents are produced in house and quality controlled, including 9 Insulin Receptor Antibody, 53 Insulin Receptor Gene, 3 Insulin Receptor Lysate, 4 Insulin Receptor Protein, 3 Insulin Receptor qPCR. All Insulin Receptor reagents are ready to use.

Insulin Receptor Protein (4)

    Insulin Receptor Antibody (9)

      Insulin Receptor cDNA Clone (53)

      NM_001079817.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_000208.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010568.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_017071.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_005587740.1

      克隆载体 cDNA 产品

      Insulin Receptor Lysate (3)

        Insulin Receptor 分子背景

        INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to theprotein kinase superfamily, and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually leads to an increase in the high affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).

        Insulin Receptor 参考文献

        • Ebina Y., et al.,(1985), The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell 40:747-758.
        • Ullrich A., et al., (1985), Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.Nature 313:756-761.
        • Grimwood J., et al.,(2004), The DNA sequence and biology of human chromosome 19.Nature 428:529-535.

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