Integrin alpha V/ITGAV Antibodies, cDNA Clones Research Reagents

ITGAV (Integrin Subunit Alpha V, also known as CD51; MSK8; VNRA; VTNR), located on 2q32.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 116038 Da protein composed of 1048 amino acids. The product of this gene belongs to the integrin alpha chain family. The integrin alpha(v)beta3, whose alpha(v) subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Diseases such as West Nile Virus and Herpes Simplex are associated with ITGAV. The related pathways of ITGAV include Integrin Pathway and Signaling by GPCR.

Integrin alpha V/ITGAV Antibody (3)

    Integrin alpha V/ITGAV cDNA Clone (27)

    NM_002210.4

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_008402.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001106549.1

    克隆载体 cDNA 产品

    In lentiviral vector

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    Integrin alpha V/ITGAV 分子背景

    ITGAV (Integrin Subunit Alpha V) is a Protein Coding gene. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. The subunit associates with beta 1, beta 3, beta 5, beta 6, and beta 8 subunits. The members of the integrin alpha V (ITGAV) family are widely expressed on many types of tumors and have been reported to be involved in angiogenesis, tumor metastases, and multicellular radioresistance. Recently, it has been shown that the polymorphism of the integrin-alpha V subunit encoded by the ITGAV gene plays a role in angiogenesis and is considered as RA susceptibility loci. The integrin alpha(v)beta3, whose alpha(v) subunit is encoded by the ITGAV gene, plays a key role in angiogenesis.

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