Integrin beta 3 Antibodies, cDNA Clones Research Reagents

ITGB3 (Integrin Subunit Beta 3, also known as GT; CD61; GP3A; BDPLT2; GPIIIa; BDPLT16), located on 17q21.32, is a Protein Coding gene. The gene produces an 87058 Da protein composed of 788 amino acids. The ITGB3 gene encodes glycoprotein IIIa (GP IIIa), the beta subunit of the platelet membrane adhesive protein receptor complex GP IIb/IIIa. ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer (CRC). Diseases such as Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16 are associated with ITGB3.

Integrin beta 3 Antibody (3)

    Integrin beta 3 cDNA Clone (52)

    NM_000212.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_016780.2

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_153720.1

    克隆载体 cDNA 产品

    In lentiviral vector

    XM_001116013.2

    克隆载体 cDNA 产品

    In lentiviral vector

    Integrin beta 3 分子背景

    ITGB3 (Integrin Subunit Beta 3) is a Protein Coding gene. The ITGB3 protein product is the integrin beta chain beta 3. ITGB3 is broadly expressed in the thyroid, endometrium, and other tissues. Integrins containing the beta(3) subunit are key players in tumor growth and metastasis. ITGB3 plays an important role in ROS-induced migration and invasion in colorectal cancer (CRC). ITGB3 is translationally activated in hypoxia and regulates malignant features, including epithelial-mesenchymal transition and cell migration, through the TGF-beta pathway, revealing a novel angle for the treatment of therapy-resistant hypoxic tumors. Bioinformatic algorithms and luciferase reporter assays revealed that integrin beta3 (ITGB3) is a direct target of miR-30a-5p. Diseases associated with ITGB3 include Glanzmann Thrombasthenia and Bleeding Disorder, Platelet-Type, 16.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.