ISG15 Proteins, Antibodies, cDNA Clones Research Reagents

ISG15 (ISG15 Ubiquitin Like Modifier, also known as G1P2; IP17; UCRP; IFI15; IMD38; hUCRP), located on 1p36.33, is a Protein Coding gene. The gene produces a 17888 Da protein composed of 165 amino acids. ISG15 is a ubiquitin-like protein that becomes conjugated to many cellular proteins upon activation by interferon-alpha (IFNA) and -beta (IFNB). It contains a unique subtype of the IFN-stimulated response element (ISRE). Diseases such as Immunodeficiency 38 With Basal Ganglia Calcification and Influenza are associated with ISG15.

ISG15 Protein (2)

    ISG15 Antibody (3)

      ISG15 cDNA Clone (18)

      NM_005101.3

      In expression vector

      In lentiviral vector

      NM_015783.3

      克隆载体 cDNA 产品

      In lentiviral vector

      ISG15 分子背景

      Interferon-induced 17 kDa protein (ISG15), a 15-kDa protein of unique primary amino acid sequence, functions intracellularly as a ubiquitin homolog and a cytokine that induces production of IFN-gamma and augments NK / lymphokine-activated killer cell proliferation and function. ISG15 is secreted from monocytes and lymphocytes. ISG15 is a ubiquitin-like molecule that is strongly upregulated by type I interferons as a primary response to diverse microbial and cellular stress stimuli. Alterations in the ISG15 signaling pathway have also been found in several human tumor entities. In addition to being stimulated by type I interferon, expression of ISG15 is greatly induced by viral or bacterial infection through the Janus kinase/signal transducer and activator of transcription (Jak / STAT) signaling pathway. After induction, ISG15 is secreted by monocytes, B- and T-lymphocytes, and fibroblasts. We demonstrate the novel way in which the function of the ISG15 protein is inhibited by influenza B virus, which strongly induces the ISG15 protein: a specific region of the influenza B virus NS1 protein, which includes part of its effector domain, blocks the covalent linkage of ISG15 to its target proteins both in vitro and in infected cells.

      ISG15 参考文献

      • Cunha J, et al. (1996) In vitro and in vivo secretion of human ISG15, an IFN-induced immunomodulatory cytokine. J Immunol. 157(9): 4100-8.
      • Andersen JB, et al. (2006) The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: friend or foe? Cytokine Growth Factor Rev. 17(6): 411-21.
      • Nuran Bektas, et al. (2008) The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer. Breast Cancer Res. 10(4): 58.

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