ITK Proteins, cDNA Clones Research Reagents

ITK (IL2 Inducible T Cell Kinase, also known as EMT; LYK; LPFS1; PSCTK2), located on 5q33.3, is a Protein Coding gene. The gene produces a 71831 Da protein composed of 620 amino acids. The encoded protein is important for proper T-cell development, T-cell receptor (TCR) signaling, cytokine release, and regulation of differentiation. Diseases such as Lymphoproliferative Syndrome 1 and Agammaglobulinemia, X-Linked are associated with ITK. The related pathways of ITK include TCR Signaling (Qiagen) and Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling.

ITK Protein (2)

    ITK cDNA Clone (30)

    NM_005546.3

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_010583.2

    克隆载体 cDNA 产品

    In lentiviral vector

    ITK Lysate (2)

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      ITK 分子背景

      IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 domain. As an intracellular kinase expressed in T-cells, IL-2-inducible T cell kinase contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. It regulates the development, function, and differentiation of conventional T-cells and nonconventional NKT-cells. IL-2-inducible T cell kinase also plays an essential role in the regulation of the adaptive immune response. Effects in IL-2-inducible T cell kinase are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk of lymphoma.

      ITK 参考文献

      • Lee SH, et al. (2011) The association of a single-nucleotide polymorphism of the IL-2 inducible T-cell Kinase gene with asthma. Ann Hum Genet. 75(3):359-69.
      • Yao HL, et al. (2010) Effect of Itk down regulation on cytokines production in Jurkat cell. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 24(5):358-61.
      • Pechloff K, et al. (2010) The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med. 207(5):1031-44.

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