JAML Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All JAML reagents are produced in house and quality controlled, including 6 JAML Antibody, 2 JAML ELISA, 27 JAML Gene, 4 JAML Lysate, 4 JAML Protein, 1 JAML qPCR. All JAML reagents are ready to use.

JAML Protein (4)

    JAML Antibody (6)

      JAML ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      JAML cDNA Clone (27)

      NM_001098526.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001286570.1

      克隆载体 cDNA 产品

      NM_001005421.4

      克隆载体 cDNA 产品

      In lentiviral vector

      JAML qPCR Primer (1)

      JAML Lysate (4)

        JAML 分子背景

        Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. It contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail involved in activation signaling. Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. The Expression of JAML/AMICA1 is restricted to the hematopoietic tissues with the exception of liver. JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells.

        JAML 参考文献

        • Moog-Lutz C, et al. (2003) JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 102(9): 3371-8.
        • Luissint AC, et al. (2008) JAM-L-mediated leukocyte adhesion to endothelial cells is regulated in cis by alpha4beta1 integrin activation. J Cell Biol. 183(6): 1159-73.
        • Guo YL, et al. (2009) Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol. 29(1): 75-83.

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