Kallikrein 8 Proteins, Antibodies, cDNA Clones Research Reagents

KLK8 (Kallikrein Related Peptidase 8, also known as NP; HNP; NRPN; PRSS19; TADG14), located on 19q13.41, is a Protein Coding gene. The gene produces a 28048 Da protein composed of 260 amino acids. KLK8 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. The protein, 72% identical to the mouse sequence, has an N-terminal signal peptide, conserved residues for protease activity, an N-linked glycosylation site, and 13 Cys residues. Diseases such as Spinal Cord Injury and Ovarian Cancer are associated with KLK8.

Kallikrein 8 Protein (1)

    Kallikrein 8 Antibody (4)

      Kallikrein 8 cDNA Clone (15)

      BC040887

      In expression vector

      In lentiviral vector

      NM_008940.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Kallikrein 8 Lysate (1)

        Kallikrein 8 分子背景

        Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. It is a serine protease that is capable of degrading some proteins such as casein, fibrinogen, kininogen, fibronectin, and collagen type IV. Kallikrein-8 / KLK8 plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway. It regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. It is involved in skin desquamation and keratinocyte proliferation and plays a role in the secondary phase of pathogenesis following spinal cord injury. It also cleaves L1CAM in response to increased neural activity. It induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Kallikrein-8 / KLK8 is expressed at high levels in serum, ascites fluid, and tumor cytosol of advanced-stage ovarian cancer patients and may serve as a marker of ovarian cancer. Kallikrein-8 / KLK8 may have potential clinical value for disease diagnosis or prognosis and it may also be a useful therapeutic target.

        Kallikrein 8 参考文献

        • Yoshida S., et al.,(1998), Sequence analysis and expression of human neuropsin cDNA and gene. Gene 213:9-16.
        • Underwood L.J., et al., (1999), Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma.Cancer Res. 59:4435-4439.
        • Mitsui S., et al.,(1999), A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain.Eur. J. Biochem. 260:627-634.

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