KDM3A Antibodies, cDNA Clones Research Reagents

KDM3A (Lysine Demethylase 3A) is a protein coding gene located on human chromosome 2p11.2. KDM3A is also known as TSGA, JMJD1, JHDM2A, JHMD2A, and JMJD1A. The human KDM3A gene encodes a 147341 Da protein containing 1321 amino acids. The KDM3A protein is ubiquitously expressed in testis, bone marrow and other tissues. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Chromatin organization. KDM3A is related to DNA-binding transcription factor activity and core promoter binding. KDM3B is an important paralog of KDM3A gene. KDM3A is associated with Familial Isolated Hypoparathyroidism.

KDM3A Antibody (1)

    KDM3A cDNA Clone (1)


    In expression vector


    KDM3A 分子背景

    KDM3A (also known as JHDM2A or JMJD1A) is an H3K9me2/1 demethylase. KDM3A performs diverse functions via the regulation of its associated genes, which are involved in spermatogenesis, metabolism, and cell differentiation. Lysine demethylase 3A (KDM3A) has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity, and tumor progression. KDM3A plays a dual role by regulating actin gene expression and binding to the actin cytoskeleton, creating a responsive "actin gate" that involves ARP2/3 activity and IFT. KDM3A played a dual role in breast cancer cell invasion and apoptosis by demethylating histone and the non-histone protein p53, respectively.

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