KIR3DL1 Antibodies, cDNA Clones Research Reagents

KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1, also known as KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR2DL5B; KIR3DL1/S1), located on 19q13.42, is a Protein Coding gene. The gene produces a 49098 Da protein composed of 444 amino acids. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Diseases such as Human Immunodeficiency Virus Type 1 and Birdshot Chorioretinopathy are associated with KIR3DL1. The related pathways of KIR3DL1 include the Immune response Role of DAP12 receptors in NK cells and Validated targets of C-MYC transcriptional activation.

KIR3DL1 Antibody (2)

    KIR3DL1 cDNA Clone (13)


    克隆载体 cDNA 产品

    In lentiviral vector

    KIR3DL1 qPCR Primer (1)

    KIR3DL1 分子背景

    KIR3DL1 is a natural killer (NK) cell receptor that recognizes the Bw4 epitope of human leukocyte antigen (HLA) class I molecules. KIR3DL1 is a polymorphic inhibitory receptor that modulates NK cell activity through interacting with HLA-A and HLA-B alleles that carry the Bw4 epitope. Amino acid polymorphisms throughout KIR3DL1 impact receptor surface expression and affinity for HLA. Genetic studies suggest that KIR3DL1 variation has functional significance in several disease states, including HIV infection. KIR3DL1 is a highly polymorphic inhibitory killer cell Ig-like receptor (KIR) implicated in resistance to viral diseases such as AIDS. KIR3DL1 contains three Ig domains and is specific for MHC class I (MHC-I) molecules belonging to the HLA-Bw4 serogroup. The receptor's second and third Ig domains confer the Bw4 specificity.

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