KLF4 is a well-known transcription factor regulating the expression of several genes including hTERT. KLF4 is a zin-finger transcription factor that plays roles in differentiation, development, and proliferation. KLF4 functions both as a tumor suppressor and oncogene depending on cell type. Kruppel like factor 4 (KLF4), a transcription factor associated with carcinogenesis and tumor progression, plays an important role in various malignancies. Kruppel-like factor 4 (KLF4), a stemness-associated transcription factor, promotes the transcription of miR-7 to repress its own translation so that a KLF4-miR-7 auto-regulatory feedback loop is established for mutual regulation of their expression.