KLF4 Antibodies, cDNA Clones Research Reagents

KLF4 (Kruppel Like Factor 4) is a protein coding gene located on human chromosome 9q31.2. KLF4 is also known as EZF and GKLF. The human KLF4 gene encodes a 54671 Da protein containing 513 amino acids. The KLF4 protein is broadly expressed in colon, esophagus and other tissues. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Preimplantation Embryo. KLF4 is related to DNA-binding transcription factor activity and transcription factor binding. KLF2 is an important paralog of KLF4 gene. KLF4 is associated with some diseases, including Secretory Meningioma and Skin Squamous Cell Carcinoma.

KLF4 Antibody (1)

    KLF4 cDNA Clone (1)


    In expression vector

    KLF4 分子背景

    KLF4 is a well-known transcription factor regulating the expression of several genes including hTERT. KLF4 is a zin-finger transcription factor that plays roles in differentiation, development, and proliferation. KLF4 functions both as a tumor suppressor and oncogene depending on cell type. Kruppel like factor 4 (KLF4), a transcription factor associated with carcinogenesis and tumor progression, plays an important role in various malignancies. Kruppel-like factor 4 (KLF4), a stemness-associated transcription factor, promotes the transcription of miR-7 to repress its own translation so that a KLF4-miR-7 auto-regulatory feedback loop is established for mutual regulation of their expression.

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