Prostate Specific Antigen/KLK3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

KLK3 (Kallikrein Related Peptidase 3, also known as APS; PSA; hK3; KLK2A1), located on 19q13.33, is a Protein Coding gene. The gene produces a 28741 Da protein composed of 261 amino acids. KLK3 is a kallikrein-like protease present in seminal plasma. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. Diseases such as Prostatitis and Urethral Stricture are associated with KLK3. The related pathways of KLK3 include Signaling by GPCR and Translation Non-genomic (rapid) action of the Androgen Receptor.

Prostate Specific Antigen/KLK3 Protein (1)

    Prostate Specific Antigen/KLK3 Antibody (9)

      Prostate Specific Antigen/KLK3 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      Prostate Specific Antigen/KLK3 cDNA Clone (13)

      NM_001648.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Prostate Specific Antigen/KLK3 qPCR Primer (1)

      Prostate Specific Antigen/KLK3 Lysate (1)

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        Prostate Specific Antigen/KLK3 分子背景

        KLK3 (Kallikrein Related Peptidase 3) is a Protein Coding gene. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease that is synthesized in the epithelial cells of the prostate gland and is present in seminal plasma. KLK3, also known as Prostate Specific Antigen (PSA), kallikrein-related peptidase 3, Gamma-seminoprotein, is a secreted protein of the glandular kallikrein subfamily of serine proteases. KLK3 contains one peptidase S1 domain. KLK3 is a glycoprotein produced almost exclusively by the prostate gland. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

        Prostate Specific Antigen/KLK3 参考文献

        • Koistinen H, et al. (2008) Development of peptides specifically modulating the activity of KLK2 and KLK3. Biol Chem. 389(6): 633-42.
        • Yousef GM, et al. (2002) Kallikreins, steroid hormones and ovarian cancer: is there a link? Minerva Endocrinol. 27(3): 157-66.
        • Parikh H, et al. (2011) Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels. Hum Genet. 129(6): 675-85.

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