LAG3 Proteins, Antibodies, cDNA Clones Research Reagents

LAG3 (Lymphocyte Activating 3, also known as CD223), located on 12p13.31, is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, and frog. The gene produces a 57449 Da protein composed of 525 amino acids. LAG3 is an immune inhibitory receptor primarily found on activated T cells. Lymphocyte-activation protein 3 belongs to the Ig superfamily and contains 4 extracellular Ig-like domains. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo.

LAG3 Protein (13)

    LAG3 Antibody (1)

      LAG3 cDNA Clone (43)

      NM_002286.5

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008479.2

      克隆载体 cDNA 产品

      In expression vector

      In lentiviral vector

      NM_212513.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001108923.2

      克隆载体 cDNA 产品

      In lentiviral vector

      LAG3 qPCR Primer (1)

      LAG3 Lysate (12)

        LAG3 分子背景

        LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.

        LAG3 参考文献

        • Sigrid Hannier. et al., 1998, The Journal of Immunology. 161(8): 4058-65.
        • Triebel F. et al., 1990, J Exp Med. 171 (5): 1393-405.
        • Baixeras E. et al., 1992, J Exp Med. 176 (2): 327-37.
        • Huard B. et al., 1997, Proc Natl Acad Sci. 94 (11): 5744-9.
        • Kisielow M. et al., 2005, Eur J Immunol. 35 (7): 2081-8.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.