LAMP2 Proteins, Antibodies, cDNA Clones Research Reagents

LAMP2 (Lysosomal Associated Membrane Protein 2, also known as DND; LAMPB; CD107b; LAMP-2; LGP-96; LGP110), located on Xq24, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 44961 Da protein composed of 410 amino acids. The protein encoded by this gene is a member of a family of membrane glycoproteins. Diseases such as Danon Disease and Rare Cardiomyopathy are associated with LAMP2. The related pathways of LAMP2 include Lysosome and Tuberculosis.

LAMP2 Protein (3)

    LAMP2 Antibody (15)

      LAMP2 cDNA Clone (53)

      BC002965

      克隆载体 cDNA 产品

      In lentiviral vector

      AK291090.1

      In expression vector

      NM_001017959.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_017068.2

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_002806377.1

      克隆载体 cDNA 产品

      In lentiviral vector

      LAMP2 Lysate (3)

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        LAMP2 分子背景

        LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. LAMP2, also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. In humans, LAMP2, the causative gene of Danon disease, located on chromosome Xq24, encodes the lysosome-associated membrane protein-2 (LAMP-2). LAMP-2 deficiency, or Danon disease, is a rare X-linked lysosomal disease characterized by cardiomyopathy, vacuolar myopathy, and mental retardation. LAMP2 cardiomyopathy is an X-linked and highly progressive myocardial storage disorder associated with diminished survival, which clinically resembles sarcomeric hypertrophic cardiomyopathy.

        LAMP2 参考文献

        • Maron BJ, et al. (2010) Profound left ventricular remodeling associated with LAMP2 cardiomyopathy. Am J Cardiol. 106(8): 1194-6.
        • Di Blasi C, et al. (2008) Danon disease: a novel LAMP2 mutation affecting the pre-mRNA splicing and causing aberrant transcripts and partial protein expression. Neuromuscul Disord. 18(12): 962-6.
        • Echaniz-Laguna A, et al. (2006) Novel Lamp-2 gene mutation and successful treatment with heart transplantation in a large family with Danon disease. Muscle Nerve. 33(3): 393-7.

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