LAMP3/CD208 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LAMP3 (Lysosomal Associated Membrane Protein 3, also known as LAMP; CD208; DCLAMP; LAMP-3; TSC403; DC LAMP; DC-LAMP), located on 3q27.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 44346 Da protein composed of 416 amino acids. Dendritic cells (DCs) are the most potent antigen-presenting cells. Diseases such as Syndromic Oculocutaneous Albinism and Psoriasis 15 are associated with LAMP3. The related pathways of LAMP3 include Lysosome.

LAMP3/CD208 Protein (2)

    LAMP3/CD208 Antibody (8)

      LAMP3/CD208 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      LAMP3/CD208 cDNA Clone (39)

      NM_014398.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_177356.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001032872.1

      克隆载体 cDNA 产品

      In lentiviral vector

      LAMP3/CD208 Lysate (2)

        LAMP3/CD208 分子背景

        Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in the activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.

        LAMP3/CD208 参考文献

        • Salaun B, et al. (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol. 33(9): 2619-29.
        • Salaun B, et al. (2004) CD208/dendritic cell-lysosomal associated membrane protein is a marker of normal and transformed type II pneumocytes. Am J Pathol. 164(3): 861-71.
        • Ishigami S, et al. (2010) Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother. 59(3): 389-95.

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