LILRA3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LILRA3 (Leukocyte Immunoglobulin Like Receptor A3, also known as HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4), located on 19q13.4, is a Protein Coding gene. The gene produces a 47472 Da protein composed of 439 amino acids. This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The related pathways of LILRA3 include Innate Immune System and Class I MHC mediated antigen processing and presentation.

LILRA3 Protein (3)

    LILRA3 Antibody (6)

      LILRA3 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      LILRA3 cDNA Clone (13)

      BC028208

      克隆载体 cDNA 产品

      In lentiviral vector

      LILRA3 qPCR Primer (1)

      LILRA3 Lysate (2)

        LILRA3 分子背景

        ILT6, also known as LILRA3, belongs to the ILT family. In humans, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immunoglobulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

        LILRA3 参考文献

        • Wi?niewski A, et al. (2004) Distribution of LILRA3 (ILT6 / LILRA3/LIR4) deletion in psoriatic patients and healthy controls. Hum Immunol. 64(4):458-61.
        • Norman PJ, et al. (2003) DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Immunogenetics. 55(3):165-71.
        • Cella M, et al. (1997) A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med. 185(10): 1743-51.

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