LILRA5 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LILRA5 (Leukocyte Immunoglobulin Like Receptor A5, also known as CD85; LIR9; CD85F; ILT11; LIR-9; ILT-11; LILRB7), located on 19q13.42, is conserved in chimpanzee, dog, mouse, and rat. The gene produces a 32755 Da protein composed of 299 amino acids. The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Sequence analysis predicted that the protein has 2 Ig domains in its extracellular part, one similar to ILT3 and the other similar to ILT10, whereas the transmembrane and cytoplasmic domains are homologous to activating ILTs, such as ILT8.

LILRA5 Protein (6)

    LILRA5 Antibody (7)

      LILRA5 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      LILRA5 cDNA Clone (39)

      NM_021250.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001081239.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001076793.1

      克隆载体 cDNA 产品

      In lentiviral vector

      LILRA5 qPCR Primer (2)

      LILRA5 Lysate (4)

        LILRA5 分子背景

        LILRA5 is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LILR are a family of receptors possessing extracellular immunoglobulin domains. They are also known as CD85, ILTs, and LIR, and can exert immunomodulatory effects on a wide range of immune cells. ILT-11 contains 2 Ig-like C2-type (immunoglobulin-like) domains. It can be detected n tissues of the hematopoietic system, including bone marrow, spleen, lymph node, and peripheral leukocytes. Crosslink of ILT-11 on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses.

        LILRA5 参考文献

        • Wende H, et al. (2000) Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. Immunogenetics. 51(8-9):703-13.
        • Jones DC, et al. (2009) Alternative mRNA splicing creates transcripts encoding soluble proteins from most LILR genes. Eur J Immunol. 39(11):3195-206.
        • Mosbruger TL, et al. (2010) Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. J Infect Dis. 201(9):1371-80.

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