Lipocalin-2/LCN2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

LCN2 (Lipocalin 2, also known as p25; 24p3; MSFI; NGAL), located on 9q34.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 22588 Da protein composed of 198 amino acids. This gene encodes a protein that belongs to the lipocalin family. LCN2 is a protein associated with neutrophil gelatinase. The LCN2 protein is believed to bind small lipophilic substances such as bacteria-derived lipopolysaccharide (LPS) and formyl peptides and may function as a modulator of inflammation. Diseases such as Klebsiella Infection and Acute Pyelonephritis are associated with LCN2.

Lipocalin-2/LCN2 Protein (4)

    Lipocalin-2/LCN2 Antibody (15)

      Lipocalin-2/LCN2 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(1)

      Lipocalin-2/LCN2 cDNA Clone (39)

      NM_005564.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008491.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_130741.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Lipocalin-2/LCN2 Lysate (4)

        Lipocalin-2/LCN2 分子背景

        Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells, like kidney tubular cells, may produce NGAL in response to various insults. This protein is released from injured tubular cells after various damaging stimuli, is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover, recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein that specifically binds organic molecules called siderophores, which are high-affinity iron chelators. NGAL, first known as an antibacterial factor of natural immunity, and an acute-phase protein, is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation, NGAL has a clear pro-tumoral effect, as has already been observed in different tumors (e.g. breast, stomach, esophagus, brain) in humans. In thyroid carcinomas, NGAL is strongly induced by NF-kB, an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus, Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation, proliferation, survival, and morphogenesis.

        Lipocalin-2/LCN2 参考文献

        • Schmidt-Ott KM, et al. (2006) Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia. Curr Opin Nephrol Hypertens. 15(4): 442-9.
        • Bolignano D, et al. (2010) Neutrophil gelatinase-associated lipocalin (NGAL) in human neoplasias: a new protein enters the scene. Cancer Lett. 288(1): 10-6.
        • Soni SS, et al. (2010) NGAL: a biomarker of acute kidney injury and other systemic conditions. Int Urol Nephrol. 42(1): 141-50.
        • Bolignano D, et al. (2010) From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology. Eur J Clin Invest. 40(3): 273-6.

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