LRG1 Proteins, Antibodies, cDNA Clones Research Reagents

LRG1 (Leucine-Rich Alpha-2-Glycoprotein 1, also known as LRG; HMFT1766), located on 19p13.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 38178 Da protein composed of 347 amino acids. The leucine-rich repeat (LRR) family of proteins, including LRG1, are involved in protein-protein interaction, signal transduction, and cell adhesion and development. Diseases such as Appendicitis and Normal Pressure Hydrocephalus are associated with LRG1. The related pathways of LRG1 include Innate Immune System.

LRG1 Protein (3)

    LRG1 Antibody (5)

      LRG1 cDNA Clone (26)

      BC034389

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_029796.2

      克隆载体 cDNA 产品

      In lentiviral vector

      LRG1 qPCR Primer (1)

      LRG1 Lysate (3)

        LRG1 分子背景

        LRG1 (Leucine-Rich Alpha-2-Glycoprotein 1) is a Protein Coding gene. LRG1 belongs to the leucine-rich repeat (LRR) family. Members of this family are involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. It contains 4 LIM zinc-binding domains and 1 Rho-GAP domain. LRG1 is involved in promoting neovascularization (new blood vessel growth) by causing a switch in transforming growth factor-beta (TGFbeta) signaling in endothelial cells. LRG1 binds to the accessory receptor endoglin and promotes signaling via the ALK1-Smad1/5/8 pathway. It may be a potential therapeutic target for the treatment of diseases where there is aberrant neovascularization. Diseases associated with LRG1 include Appendicitis and Normal Pressure Hydrocephalus.

        LRG1 参考文献

        • O Donnell LC. et al., 2002, J Leukoc Biol. 72 (3): 478-85.
        • Li X. et al., 2007, Neurosci Lett. 413 (2): 141-4.
        • Ramachandran P. et al., 2006, J Proteome Res. 5 (6): 1493-503.

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