LRP6 Antibodies, cDNA Clones Research Reagents

LRP6 (LDL Receptor Related Protein 6) is a protein coding gene located on human chromosome 12p13.2. LRP6 is also known as ADCAD2 and STHAG7. The human LRP6 gene encodes a 180429 Da protein containing 1613 amino acids. The LRP6 protein is ubiquitously expressed in placenta, ovary and other tissues. Among its related pathways are Signaling by GPCR and S45 mutants of beta-catenin arent phosphorylated. LRP6 is related to protein homodimerization activity and signaling receptor binding. LRP5 is an important paralog of LRP6 gene. LRP6 is associated with some diseases, including Coronary Artery Disease, Autosomal Dominant 2 and Tooth Agenesis, Selective, 7.

LRP6 Antibody (1)

    LRP6 cDNA Clone (13)


    克隆载体 cDNA 产品

    In lentiviral vector


    LRP6 分子背景

    Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in the development and progression of colorectal cancer. This gene, termed LDL receptor-related protein 6 (LRP6), encodes a transmembrane protein that has 71% identity and is structurally similar to the protein encoded by LRP5, a proposed candidate gene for type 1 diabetes located on human chromosome 11q13. LRP6 maps to human chromosome 12p11-p13.

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