LRRC32 Proteins, cDNA Clones Research Reagents

LRRC32 (Leucine-Rich Repeat Containing 32, also known as GARP; CPPRDD; D11S833E), located on 11q13.5, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 71979 Da protein composed of 662 amino acids. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32 is a T(reg)-specific receptor that binds latent TGF-beta and dominantly controls FOXP3 and the regulatory phenotype via a positive feedback loop. RRC32 associates with latent TGF-beta dimers on the surface of regulatory T cells and platelets and regulates TGF-beta bioavailability.

LRRC32 Protein (2)

    LRRC32 cDNA Clone (16)

    BC070079

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001113379.2

    In expression vector

    LRRC32 qPCR Primer (1)

    LRRC32 Lysate (1)

      更多受客户欢迎的产品

      LRRC32 分子背景

      LRRC32 (Leucine-Rich Repeat Containing 32) is a Protein Coding gene. This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. LRRC32, also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). LRRC32 is a T(reg)-specific receptor that binds latent TGF-beta and dominantly controls FOXP3 and the regulatory phenotype via a positive feedback loop. It belongs to the LRRC32/LRRC33 family and is broadly expressed in the placenta, lung, and other tissues. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. An important paralog of this gene is NRROS.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.