Leukotriene A4 Hydrolase Proteins, Antibodies, cDNA Clones Research Reagents

LTA4H (Leukotriene A4 Hydrolase), located on 12q23.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. The gene produces a 69285 Da protein composed of 611 amino acids. The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. Diseases such as Tuberculous Meningitis and Intestinal Tuberculosis are associated with LTA4H. The related pathways of LTA4H include Eicosanoid Synthesis and Arachidonic acid metabolism.

Leukotriene A4 Hydrolase Protein (2)

    Leukotriene A4 Hydrolase Antibody (7)

      Leukotriene A4 Hydrolase cDNA Clone (32)

      NM_000895.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008517.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001030031.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Leukotriene A4 Hydrolase Lysate (2)

        Leukotriene A4 Hydrolase 分子背景

        Leukotriene A-4 hydrolase, also known as LTA-4 hydrolase, Leukotriene A (4) hydrolase, LTA4H, and LTA4, is a cytoplasm protein that belongs to the peptidase M1 family. LTA4H hydrolyzes an epoxide moiety of leukotriene A4 (LTA-4) to form leukotriene B4 (LTB-4). This enzyme also has some peptidase activity. The leukotrienes (LTs) are a class of structurally related lipid mediators involved in the development and maintenance of inflammatory and allergic reactions. In the biosynthesis of LTs, arachidonic acid was converted into the unstable intermediate epoxide LTA4, which may, in turn, be conjugated with glutathione to form the spasmogenic LTC4, or hydrolyzed into the pro-inflammatory lipid mediator LTB4 in a reaction catalyzed by Leukotriene A4 hydrolase (LTA4H). LTB4 is a classical chemoattractant of human neutrophils and triggers adherence and aggregation of leukocytes to vascular endothelium, and also modulates immune responses. As a bifunctional zinc metalloenzyme, LTA4H also exhibits an anion-dependant arginyl aminopeptidase activity of high efficiency and specificity in addition to its epoxide hydrolase activity. LTA4H is regarded as a therapeutic target for inflammation.

        Leukotriene A4 Hydrolase 参考文献

        • Mancini, JA. et al.,1995, Eur. J. Biochem. 231: 65-71.
        • Orning, L. et al., 1994, J. Biol. Chem. 269: 11269-73.
        • Rudberg, PC. et al., 2004, J. Biol. Chem. 279: 27376-82.
        • Qiu, H. et al., 2006, Proc. Natl. Acad. Sci. USA. 103: 8161-6.

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