LTBR Proteins, Antibodies, cDNA Clones Research Reagents

LTBR (Lymphotoxin Beta Receptor, also known as TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III), located on 12p13.31, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 46709 Da protein composed of 435 amino acids. This gene encodes a member of the tumor necrosis factor receptor superfamily. Diseases such as Bronchiectasis With Or Without Elevated Sweat Chloride 2 and Cone-Rod Dystrophy 2 are associated with LTBR. The related pathways of LTBR include NF-KappaB Family Pathway and LT-BetaR Pathway.

LTBR Protein (4)

    LTBR Antibody (3)

      LTBR cDNA Clone (51)

      NM_002342.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_010736.3
      NM_001008315.1

      克隆载体 cDNA 产品

      In lentiviral vector

      XM_001103746.2

      克隆载体 cDNA 产品

      In lentiviral vector

      LTBR qPCR Primer (2)

      LTBR Lysate (4)

        LTBR 分子背景

        LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) is a member of the tumor necrosis factor (TNF) family of receptors. The tumor necrosis factor receptor is a trimeric cytokine receptor that binds tumor necrosis factors. The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response. LTBR is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. LTBR specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphotoxin-beta). LTBR and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of this protein can trigger apoptosis. Not only does the LTBR help trigger apoptosis, but it can also lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. It is also essential for the development and organization of the secondary lymphoid organs and chemokine release.

        LTBR 参考文献

        • Summers deLuca L, et al. (2011) A LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells. Proc Natl Acad Sci. 108(5):2046-51.
        • Bista P, et al. (2010) TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem. 285(17):12971-8.
        • Xu Y, et al. (2011) Adiponectin inhibits lymphotoxin-β receptor-mediated NF-κB signaling in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 404(4):1060-4.

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