LYPLA2 Proteins, Antibodies, cDNA Clones Research Reagents

LYPLA2 (Lysophospholipase 2, also known as APT2; APT-2; DJ886K2.4), located on 1p36.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. The gene produces a 24737 Da protein composed of 231 amino acids. Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. Diseases such as Hypotonia-Cystinuria Syndrome are associated with LYPLA2. The related pathways of LYPLA2 include L1CAM interactions and Developmental Biology.

LYPLA2 Protein (1)

    LYPLA2 Antibody (1)

      LYPLA2 cDNA Clone (45)

      NM_007260.2

      克隆载体 cDNA 产品

      In lentiviral vector

      BC017034

      In expression vector

      In lentiviral vector

      NM_011942.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_031342.1

      克隆载体 cDNA 产品

      In lentiviral vector

      LYPLA2 qPCR Primer (1)

      LYPLA2 分子背景

      Lysophospholipase II (LYPLA2, LPL-II, or LysoPLA II), also known as Acyl-protein thioesterase 2 (APT-2), belongs to the AB hydrolase 2 family. This enzyme has lysophospholipase activity and may hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acyl-protein thioesterase 1 (APT-1) and Acyl-protein thioesterase 2 (APT-2) are cytosolic lysophospholipids hydrolyzing enzymes. The serum activity of APT-1 may play an important role in the determination of the concentration of des-acyl ghrelin in circulation, especially under septic inflammation. APT-2/LYPLA2 is expressed both in CHO-K1 and HeLa cells and its overexpression increased the deacylation rate of single acylated GAP-43 and affected the steady-state localization of diacylated GAP-43 and H-Ras. Thus, the results demonstrate that APT-2/LYPLA2 is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP-43 subcellular distribution.

      LYPLA2 参考文献

      • Satou M, et al. (2010) Identification and characterization of acyl-protein thioesterase 1/lysophospholipase I as a ghrelin deacylation/lysophospholipid hydrolyzing enzyme in fetal bovine serum and conditioned medium. Endocrinology. 151(10): 4765-75.
      • Tomatis VM, et al. (2010) Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43. PLoS One. 5(11): e15045.

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