Germinal Center Kinase/MAP4K2 Proteins, cDNA Clones Research Reagents

MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2, also known as GCK; BL44; RAB8IP), located on 11q13.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. The gene produces a 91556 Da protein composed of 820 amino acids. The protein encoded by this gene is a member of the serine/threonine-protein kinase family. Diseases such as Cerebral Cavernous Malformations 2 are associated with MAP4K2. The related pathways of MAP4K2 include the Signal transduction_JNK pathway and TRAF Pathway.

Germinal Center Kinase/MAP4K2 Protein (1)

    Germinal Center Kinase/MAP4K2 cDNA Clone (2)


    In expression vector

    In lentiviral vector

    Germinal Center Kinase/MAP4K2 qPCR Primer (1)

    Germinal Center Kinase/MAP4K2 Lysate (1)

      Germinal Center Kinase/MAP4K2 分子背景

      Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of the germinal center, where it may participate in B-cell differentiation. MAP4K2 can be activated by TNF-alpha and has been shown to specifically activate MAP kinases. It is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1 / MEKK1. MAP4K2 enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. It may also play a role in the regulation of vesicle targeting or fusion.

      Germinal Center Kinase/MAP4K2 参考文献

      • Katz P, et al.,1994, J Biol Chem 269 (24): 16802-9.
      • Ren, M; et al., 1996,  Proc. Natl. Acad. Sci. USA. 93 (10): 5151-5.
      • Chadee D.N., et al., 2002, Mol. Cell. Biol. 22:737-49.
      • Wissing J., et al., 2007, Mol. Cell. Proteomics 6:537-47.
      • Oppermann F.S., et al., 2009, Mol. Cell. Proteomics 8:1751-64.

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