MAPKAPK3 Proteins, Antibodies, cDNA Clones Research Reagents

MAPKAPK3 (MAPK Activated Protein Kinase 3, also known as 3PK; MK3; MK-3; MDPT3; MAPKAP3; MAPKAP-K3; MAPKAPK-3), located on 3p21.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. The gene produces a 42987 Da protein composed of 382 amino acids. This gene encodes a member of the Ser/Thr protein kinase family. Diseases such as Macular Dystrophy, Patterned, 3, and Patterned Macular Dystrophy are associated with MAPKAPK3. The related pathways of MAPKAPK3 include Signaling by GPCR and VEGF Signaling.

MAPKAPK3 Protein (1)

    MAPKAPK3 Antibody (2)

      MAPKAPK3 cDNA Clone (30)

      NM_004635.3

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_178907.3

      克隆载体 cDNA 产品

      In lentiviral vector

      MAPKAPK3 Lysate (1)

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        MAPKAPK3 分子背景

        The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identified and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is widely expressed in human tissues, with a higher expression level observed in the heart and skeletal muscle. No expression in the brain. MAPKAPK-3 is unique since it was shown to be activated by three members of the MAPK family, namely extracellular-signal-regulated kinase (ERK), p38, and Jun-N-terminal kinase (JNK). It is highly activated both by mitogens and by stress-inducing agents or proinflammatory cytokines and translocates to the cytoplasm from the nucleus. MAPKAPK-3 is exclusively activated via the classical MAPK cascade, while stress-induced activation of MAPKAPK-3 is mainly mediated by p38, however, the mechanism defining the specificity remains unknown.

        MAPKAPK3 参考文献

        • McLaughlin, M.M. et al., 1996, J. Biol. Chem. 271:8488-8492.
        • Tanoue, T. et al., 2001, EMBO J. 20: 466-479.
        • Neufeld, B. et al., 2000, J. Biol. Chem. 275: 20239-20242.
        • Zakowski,V. et al., 2004, Exp Cell Res. 299: 101-109.
        • Voncken, J. W. et al., 2005, J. Biol. Chem. 280: 5178-5187.

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