MART-1/MLANA (蛋白 | 抗体 | cDNA 克隆 | ELISA 试剂盒)

All MART-1/MLANA reagents are produced in house and quality controlled, including 1 MART-1/MLANA Antibody, 15 MART-1/MLANA Gene, 1 MART-1/MLANA qPCR. All MART-1/MLANA reagents are ready to use.

MART-1/MLANA Antibody (1)

    MART-1/MLANA cDNA Clone (15)

    BC014423

    克隆载体 cDNA 产品

    In lentiviral vector

    MART-1/MLANA qPCR Primer (1)

    MART-1/MLANA 分子背景

    MART-1 is a hydrophobic transmembrane protein without glycosylation sites highly enriched in early melanosomes. MART-1 is necessary for gp1 function, another antigen associated to cutaneous melanom, involved in the regulation of melanosome formation. MART-1 is expressed in skin and retinae melanocytes and in the majority of melanoma tumors, but it is absent from other tissues and tumors. It was isolated thanks to the specific recognition by T lymphocytes of MART-1 derived peptides, specially in the context of the HLA-A21 haplotype, present in tumor infiltrates from melanoma patients. Thus, MART-1 is immunogenic in humans and has been widely exploited to induce anti-melanoma immunity in patients by means of several vaccination strategies.

    MART-1/MLANA 参考文献

    • Barrio MM, Abes R, Colombo M, et al. Human Macrophages and Dendritic Cells Can Equally Present MART-1 Antigen to CD8+ T Cells after Phagocytosis of Gamma-Irradiated Melanoma Cells. Chatenoud L, ed. PLoS ONE. 2012;7(7):e40311.

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