Mast Cell Protease-1/MCPT-1 Proteins, Antibodies, cDNA Clones Research Reagents

All Mast Cell Protease-1/MCPT-1 reagents are produced in house and quality controlled, including 3 Mast Cell Protease-1/MCPT-1 Antibody, 13 Mast Cell Protease-1/MCPT-1 Gene, 1 Mast Cell Protease-1/MCPT-1 Lysate, 1 Mast Cell Protease-1/MCPT-1 Protein, 1 Mast Cell Protease-1/MCPT-1 qPCR. All Mast Cell Protease-1/MCPT-1 reagents are ready to use.

Mast Cell Protease-1/MCPT-1 Protein (1)

    Mast Cell Protease-1/MCPT-1 Antibody (3)

      Mast Cell Protease-1/MCPT-1 cDNA Clone (13)

      NM_008570.1

      克隆载体 cDNA 产品

      In lentiviral vector

      Mast Cell Protease-1/MCPT-1 qPCR Primer (1)

      Mast Cell Protease-1/MCPT-1 Lysate (1)

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        Mast Cell Protease-1/MCPT-1 分子背景

        Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared with nanograms of mMCP-2 are detected in peripheral blood during intestinal nematode infection. mMCP-1 isolated from serum is complexed with serpins and both the accumulation and the longevity of mMCP-1 in blood is due to complex formation, protecting it from a pathway that rapidly clears mMCP-2, which is unable to form complexes with serpins. The mucosal mast cell (MMC) granule-specific beta-chymase, mouse mast cell protease-1 (mMCP-1), is released systemically into the bloodstream early in nematode infection before parasite-specific IgE responses develop and TGF-beta1 induces constitutive release of mMCP-1 by homologues of MMC in vitro. Expression of mMCP-1 is largely restricted to intraepithelial MMC and is thought to play a role in the regulation of epithelial permeability. Its activation is completed by the removal of a two residue N-terminal propeptide by a dipeptidyl peptidase (Cathepsin C). MCPT-1 is upregulated in the intestine in response to nematode infection, or in systemic mucosa in response to anaphylaxis. Like human α-chymase, MCPT-1 is capable of the conversion of angiotensin I to angiotensin II, which plays a key role in the regulation of arterial pressure. The intestinal inflammation associated with gastrointestinal helminths is partly mediated by mMCP-1.

        Mast Cell Protease-1/MCPT-1 参考文献

        • Pemberton AD, et al. (2003) Purification and characterization of mouse mast cell proteinase-2 and the differential expression and release of mouse mast cell proteinase-1 and -2 in vivo. Clin Exp Allergy. 33(7): 1005-12.
        • Brown JK, et al. (2003) Constitutive secretion of the granule chymase mouse mast cell protease-1 and the chemokine, CCL2, by mucosal mast cell homologues. Clin Exp Allergy. 33(1): 132-46.
        • Lawrence CE, et al. (2004) Mouse mast cell protease-1 is required for the enteropathy induced by gastrointestinal helminth infection in the mouse. Gastroenterology. 127(1): 155-65.
        • Pemberton AD, et al. (2006) Anaphylactic release of mucosal mast cell granule proteases: role of serpins in the differential clearance of mouse mast cell proteases-1 and -2. J Immunol. 176(2): 899-904.

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