Mesothelin Proteins, Antibodies, cDNA Clones Research Reagents

MSLN (Mesothelin, also known as MPF; SMRP), located on 16p13.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and frog. The gene produces a 68986 Da protein composed of 630 amino acids. This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor, and mesothelin. Diseases such as Mesothelioma, Malignant, and Asbestosis are associated with MSLN. The related pathways of MSLN include the Metabolism of proteins and Adhesion.

Mesothelin Protein (7)

    Mesothelin Antibody (4)

      Mesothelin cDNA Clone (16)

      BC009272

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_013404.4

      In expression vector

      NM_005823.6

      In expression vector

      Mesothelin qPCR Primer (1)

      Mesothelin Lysate (5)

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        Mesothelin 分子背景

        The megakaryocyte potentiating factor belongs to the mesothelin family. This family is comprised of several mammalian pre-pro-megakaryocyte potentiating factor precursor (MPF) or mesothelin proteins. Mesothelin is a glycosylphosphatidylinositol-linked glycoprotein highly expressed in mesothelial cells, mesotheliomas, and ovarian cancer, but the biological function of the protein is not known. Megakaryocyte potentiating factor is highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). It interacts with MUC16 and potentiates megakaryocyte colony formation in vitro. Megakaryocyte potentiating factor is secreted by several mesothelioma cell lines and is frequently elevated in the blood of patients with mesothelioma. Measurement of this protein may be useful in following the response of mesothelioma to treatment.

        Mesothelin 参考文献

        • Chang MC, et al. (2012) Mesothelin enhances invasion of ovarian cancer by inducing MMP-7 through MAPK/ERK and JNK pathways. Biochem J. 442 (2): 293-302.
        • Nelson HH, et al. (2011) The relationship between tumor MSLN methylation and serum mesothelin (SMRP) in mesothelioma. Epigenetics. 6 (8): 1029-34.
        • Bournet B, et al. (2012) Gene expression signature of advanced pancreatic ductal adenocarcinoma using low density array on endoscopic ultrasound-guided fine needle aspiration samples. Pancreatology. 12 (1): 27-34.

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