MIA2 Antibodies, cDNA Clones Research Reagents

MIA2 (MIA SH3 Domain ER Export Factor 2, also known as MEA6; MGEA; TALI; MGEA6; CTAGE5; MGEA11), located on 14q13.2, is a Protein Coding gene. This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low-density lipoproteins (pre-VLDLs). MIA2, a protein facilitating protein secretion, is an HNF1A target. It belongs to the MIA/OTOR family. The selective expression of MIA2 in hepatocytes is controlled by the hepatocyte nuclear factor (HNF) 1 binding site in the MIA2 promotor.

MIA2 Antibody (1)

    MIA2 cDNA Clone (13)

    BC130537

    克隆载体 cDNA 产品

    In lentiviral vector

    MIA2 qPCR Primer (1)

    MIA2 分子背景

    Melanoma inhibitory activity 2 (MIA2) is a novel gene of the MIA gene family. The novel human gene MIA2 encoding a melanoma inhibitory activity (MIA) homologous protein was identified by a GenBank(TM) search. MIA2, together with MIA, belongs to the novel MIA gene family sharing important structural features, significant homology at both the nucleotide and protein levels, and similar genomic organization. MIA2, a protein facilitating protein secretion, is an HNF1A target. The selective expression of MIA2 in hepatocytes is controlled by the hepatocyte nuclear factor (HNF) 1 binding site in the MIA2 promotor. In contrast, in most hepatocellular carcinomas (HCC) MIA2 expression is down-regulated or lost. Full-length hepatic Mia2 structurally and functionally resembled the related Mia3 protein. Mia2 localized to endoplasmic reticulum (ER) exit sites. Mia2's cytosolic C terminus interacted directly with COPII proteins Sec23 and Sec24, whereas its lumenal SH3 domain may facilitate interactions with secretory cargo.

    MIA2 参考文献

    • Pitman JL, et al. (2011) Reduced cholesterol and triglycerides in mice with a mutation in mia2, a liver protein that localizes to er exit sites. J Lipid Res 52 (10): 1775-1786.
    • Hellerbrand C, et al. (2008) The novel gene mia2 acts as a tumour suppressor in hepatocellular carcinoma. Gut 57 (2): 243-251.
    • Bosserhoff AK, et al. (2003) Specific expression and regulation of the new melanoma inhibitory activity-related gene mia2 in hepatocytes. J Biol Chem 278 (17): 15225-15231.

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