Midkine Proteins, Antibodies, cDNA Clones Research Reagents

All Midkine reagents are produced in house and quality controlled, including 1 Midkine Antibody, 26 Midkine Gene, 1 Midkine Lysate, 1 Midkine Protein, 1 Midkine qPCR. All Midkine reagents are ready to use.

Midkine Protein (1)

    Midkine Antibody (1)

      Midkine cDNA Clone (26)

      NM_001012333.1

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_001012336.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Midkine qPCR Primer (1)

      Midkine Lysate (1)

        Midkine 分子背景

        Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angiogenesis. Midkine binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Midkine is involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. Midkine exhibited increased expression in the breast carcinomas but showed much lower expression in the normal breast tissue. Thus, it can be used as breast carcinomas marker.

        Midkine 参考文献

        • Kadomatsu K, et al. (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett. 204(2): 127-43.
        • Muramatsu H, et al. (1993) Midkine, a retinoic acid-inducible growth/differentiation factor: immunochemical evidence for the function and distribution. Dev Biol. 159(2): 392-402.
        • Muramatsu T. (2002) Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis. J Biochem. 132(3): 359-71.
        • Kadomatsu K, et al. (2004) Midkine and pleiotrophin in neural development and cancer. Cancer Lett. 204(2): 127-43.

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