MKK4 Proteins, Antibodies, cDNA Clones Research Reagents

All MKK4 reagents are produced in house and quality controlled, including 1 MKK4 Antibody, 16 MKK4 Gene, 1 MKK4 Lysate, 1 MKK4 Protein, 1 MKK4 qPCR. All MKK4 reagents are ready to use.

MKK4 Protein (1)

    MKK4 Antibody (1)

      MKK4 cDNA Clone (16)


      In expression vector


      克隆载体 cDNA 产品

      In lentiviral vector

      MKK4 qPCR Primer (1)

      MKK4 Lysate (1)

        MKK4 分子背景

        Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK and MAP2K4, is a protein which belongs to theprotein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase which is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / JNKK1 has been shown to activate MAPK8 / JNK1, MAPK9 / JNK2, and MAPK14 / p38, but not MAPK1 / ERK2 or MAPK3 / ERK1. MAP2K4 / JNKK1 is phosphorylated, and thus activated by MAP3K1 / MEKK. The stress-activated protein kinase (SAPK) pathways represent phosphorylation cascades that convey pro-apoptotic signals. The mitogen-activated protein kinase kinase (MAPKK) homolog MAP2K4 ( MKK4, SEK, JNKK1 ) is a centrally-placed mediator of the SAPK pathways.

        MKK4 参考文献

        • Lin A, et al.,1995, Science 268 (5208): 286-90.
        • Su,G.H. et al., 2002, Hum Mutat. 19 (1):81.
        • Lee, et al., 2002, Proc. Natl. Acad. Sci. USA. 99 (22): 14189-94.
        • Bouzakri,K. et al., 2007, J Biol Chem. 282 (11):7783-9.

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