MMP-8 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

MMP8 (Matrix Metallopeptidase 8, also known as HNC; CLG1; MMP-8; PMNL-CL), located on 11q22.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish. The gene produces a 53412 Da protein composed of 467 amino acids. This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. Diseases such as Preterm Premature Rupture Of The Membranes and Gingivitis are associated with MMP8. The related pathways of MMP8 include Degradation of the extracellular matrix and Innate Immune System.

MMP-8 Protein (4)

    MMP-8 Antibody (10)

      MMP-8 ELISA 试剂盒(即用型)& ELISA 抗体对套装(非即用型)(2)

      MMP-8 cDNA Clone (28)

      NM_002424.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_008611.4

      克隆载体 cDNA 产品

      In lentiviral vector

      MMP-8 Lysate (4)

        MMP-8 分子背景

        Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Neutrophil collagenase, also known as Matrix metalloproteinase-8, MMP-8, and CLG1, is a member of the peptidase M1A family. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 in the tumor may have a protective effect against lymph node metastasis. MMP-8 may affect the metastatic behavior of breast cancer cells through protection against lymph node metastasis, underlining the importance of anti-target identification in drug development. MMP-8 participates in wound repair by contributing to the resolution of inflammation and open the possibility to develop new strategies for treating wound healing defects.

        MMP-8 参考文献

        • Hasty K.A., et al.,(1990), Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J. Biol. Chem. 265:11421-11424.
        • Blaeser J., et al., (1991), Mercurial activation of human polymorphonuclear leucocyte procollagenase.Eur. J. Biochem. 202:1223-1230.
        • Blaeser J., et al.,(1991), Mercurial activation of human polymorphonuclear leucocyte procollagenase. Eur. J. Biochem. 202:1223-1230.

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