MOB4 Antibodies, cDNA Clones Research Reagents

MOB4 (MOB Family Member 4, Phocein, also known as 2C4D; MOB1; MOB3; PHOCN; PREI3; CGI-95; MOBKL3), located on 2q33.1, is a Protein Coding gene. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. MOB4 belongs to the MOB1/phocein family. It is widely expressed in the adrenal, esophagus, and other tissues. MOB4 also plays a role in membrane trafficking, specifically in membrane budding reactions.

MOB4 Antibody (2)

    MOB4 cDNA Clone (32)

    NM_015387.4

    克隆载体 cDNA 产品

    In lentiviral vector

    BC005237

    In expression vector

    In lentiviral vector

    NM_025283.3

    克隆载体 cDNA 产品

    In lentiviral vector

    MOB4 qPCR Primer (1)

    MOB4 分子背景

    MOB4 (MOB Family Member 4, Phocein) is a Protein Coding gene. The MOB4 gene, located on 2q33.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. MOB4 belongs to the MOB1/phocein family. 3 alternatively spliced human isoforms have been reported. This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. MOB4 may also play a role in membrane trafficking, specifically in membrane budding reactions. MOB4 is widely expressed in the adrenal, esophagus, and other tissues. Diseases associated with MOB4 include Cerebral Cavernous Malformations 3 and Febrile Seizures, Familial, 6.

    MOB4 参考文献

    • Hirabayashi S, et al. (2008) Threonine 74 of mob1 is a putative key phosphorylation site by mst2 to form the scaffold to activate nuclear dbf2-related kinase 1. Oncogene 27 (31): 4281-4292.
    • Chen M, et al. (2018) The mst4-mob4 complex disrupts the mst1-mob1 complex in the hippo-yap pathway and plays a pro-oncogenic role in pancreatic cancer. J Biol Chem 293 (37): 14455-14469.
    • Bailly YJ, et al. (2007) Phocein: A potential actor in vesicular trafficking at purkinje cell dendritic spines. Cerebellum 6 (4): 344-352.

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