MTFR1 Antibodies, cDNA Clones Research Reagents

MTFR1 (Mitochondrial Fission Regulator 1, also known as CHPPR; FAM54A2), located on 8q13.1, is a Protein Coding gene. This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. MTFR1 belongs to the MTFR1 family. MTFR1 may play a role in mitochondrial aerobic respiration, and may also regulate mitochondrial organization and fission. MTFR1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction by suppressing Mtfr1 translation.

MTFR1 Antibody (1)

    MTFR1 cDNA Clone (45)

    BC036116

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_026182.5

    克隆载体 cDNA 产品

    In lentiviral vector

    NM_001100977.1

    克隆载体 cDNA 产品

    In lentiviral vector

    MTFR1 qPCR Primer (1)

    MTFR1 分子背景

    The Mtfr1 has been confirmed as a targeted gene of miR-324-5p through miRTarBase software and western blot. miR-324-5p protects against oxidative stress-induced EPCs injury by regulating Mtfr1. Knocking down Mtfr1 suppresses mitochondrial fission, apoptosis, and myocardial infarction. Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction by suppressing Mtfr1 translation. Mtfr1 (mitochondrial fission regulator 1), is a gene involved in the regulation of antioxidant activity in the mouse testis. Mtfr1 protects the male gonads against oxidative stress. Mtfr1/Chppr is a nuclear gene coding for a mitochondrial protein capable of inducing fission of this organelle in a sequence-specific manner.

    MTFR1 参考文献

    • Wang K, et al. (2015) Nfat4-dependent mir-324-5p regulates mitochondrial morphology and cardiomyocyte cell death by targeting mtfr1. Cell Death Dis 6 (12): e2007.
    • Monticone M, et al. (2007) Impaired expression of genes coding for reactive oxygen species scavenging enzymes in testes of mtfr1/chppr-deficient mice. Reproduction 134 (3): 483-492.
    • Chen P, et al. (2019) Mir-324-5p protects against oxidative stress-induced endothelial progenitor cell injury by targeting mtfr1. J Cell Physiol 234 (12): 22082-22092.

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