Myelin Oligodendrocyte Glycoprotein Proteins, Antibodies, cDNA Clones Research Reagents

MOG (Myelin Oligodendrocyte Glycoprotein, also known as BTN6; BTNL11; MOGIG2; NRCLP7), located on 6p22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Diseases such as Narcolepsy 7 and Rubella are associated with MOG. The related pathways of MOG include Neural Stem Cells and Lineage-specific Markers.

Myelin Oligodendrocyte Glycoprotein Protein (2)

    Myelin Oligodendrocyte Glycoprotein Antibody (6)

      Myelin Oligodendrocyte Glycoprotein cDNA Clone (27)

      NM_206809.2

      克隆载体 cDNA 产品

      In lentiviral vector

      NM_206814.5

      In expression vector

      NM_010814.2

      克隆载体 cDNA 产品

      In lentiviral vector

      Myelin Oligodendrocyte Glycoprotein IP Kit (1)

      Myelin Oligodendrocyte Glycoprotein 分子背景

      Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to the immunoglobulin superfamily and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately 0.1% total proteins) in the oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce demyelinating multiple sclerosis-like diseases in experimental animals.

      Myelin Oligodendrocyte Glycoprotein 参考文献

      • Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
      • Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
      • Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.

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